
米坤,博士,电子科技大学医学院教授,硕士生导师,主要研究方向为肿瘤侵袭转移机制、肿瘤干细胞、肿瘤微环境和三维细胞培养模型等。先后主持多项国家自然科学基金,四川省科技厅课题及省卫建委课题。在Annals of Surgical Oncology,International Journal of Nanomedicine等国内外学术期刊发表论文10余篇。
学术经历:
(1)2025.01至今,四川省肿瘤医院,研究员;
(2)2009.07-2024.12,四川省肿瘤医院,副研究员;
(3)2003.09–2009.06四川大学华西医院,博士;
(3)1999.09.11–2003.06四川大学生命科学学院,本科;
科研项目:
(1)国家自然科学基金项目:
三维模型调控EMT/MET表型转化探讨肿瘤微环境在乳腺癌侵袭转移中的作用机制,项目编号:81872402,2019年;主持
三维微环境调控肿瘤干细胞EMT表型及其在乳腺癌侵袭转移中的分子机制研究,项目编号:81201826,2013年;主持
(2)四川省科技厅项目:
肿瘤干细胞三维培养模型的建立及其在药物筛选中的应用,项目编号:2022YFS0215,2022年;主持
蛋白组学鉴定头颈鳞癌肿瘤干细胞药物耐受相关蛋白质及靶向药物筛选研究,项目编号:2014JY0077,2014年;主持
(3)四川省卫生厅项目:
三维体外模型探讨内质网应激抑制头颈鳞癌耐药性的作用及机制,项目编号:21PJ114;2021年;主持
主要研究成果:
[1]Hao Wang,Kun Mi*, Emerging roles of endoplasmic reticulum stress in the cellular plasticity of cancer cells. Frontiers in Oncology, 2023,13:1110881.
[2]Qifeng Wang, Bangrong Cao, Lin Peng, Wei Dai, Yinchun Jiang, Tianpeng Xie, Qiang Fang, Yi Wang, Lei Wu, Yongtao Han, Jinyi Lang,Kun Mi*, Development and Validation of a Practical Prognostic Coagulation Index for Patients with Esophageal Squamous Cell Cancer. Annals of Surgical Oncology, 2021, 28(13): 8450-8461.
[3]Qifeng Wang, Bangrong Cao,Kun Mi*, ASO Author Reflections: Prognostic Role of a Coagulation Index for Patients with Esophageal Squamous Cell Cancer. Annals of Surgical Oncology, 2021, 28(13):8462-8463.
[4]Bangrong Cao, Liping Zhang, Huifen Liu, Shiqi Ma,Kun Mi*, The Dynamic Expression of Potential Mediators of Severe Acute Respiratory Syndrome Coronavirus 2 Cellular Entry in Fetal, Neonatal, and Adult Rhesus Monkeys. Frontiers in Genetics, 2021, 11: 607479.
[5]Cuirong Gu, Yue Zhang, Dan Chen, Huifen Liu,Kun Mi*, Tunicamycin-induced endoplasmic reticulum stress inhibits chemoresistance of FaDu hypopharyngeal carcinoma cells in 3D collagen I cultures and in vivo. Experimental Cell Research, 2021, 405(2): 112725.
[6]Huifen Liu, Hao Wang, Dan Chen, Cuirong Gu, Jianming Huang,Kun Mi*, Endoplasmic reticulum stress inhibits 3D Matrigel-induced vasculogenic mimicry of breast cancer cells via TGF-β1/Smad2/3 and β-catenin signaling. FEBS Open Bio, 2021, 11(9):2607-2618.
[7]辜翠容,刘惠芬,王浩,黄灵潇,黄建鸣,米坤*. Matrigel三维培养模型对乳腺癌细胞整合素β1的定位及胞外基质粘附的影响[J]. 2019,32(4):299-304.
[8]刘惠芬,张月,米坤*,辜翠容,王浩,魏阳,蒋文军,黄建鸣.Ⅰ型鼠尾胶原三维培养模型对乳腺癌细胞耐药性的影响研究[J].西部医学,2019,31(11):1663-1667.
[9]Kun Mi, Zhihua Xing, CD44+CD24- breast cancer cells exhibit phenotypic reversion in three-dimensional self-assembling peptide RADA16 nanofiber scaffold. International Journal of Nanomedicine, 2015, 10: 3043-3053.
[10]Kun Mi, Guixia Wang, Zijia Liu,Zhihua Feng, Ben Huang, Xiaojun Zhao, Influence of a Self-Assembling Peptide, RADA16, Compared with Collagen I and Matrigel on the Malignant Phenotype of Human Breast-Cancer Cells in 3D Cultures and in vivo.Macromolecular Bioscience,2009, 5(9): 437-443.