杨牧，博士，教授，博士研究生导师。2012年至2019年就职于加拿大McGill大学附属Montréal Neurological Institute and Hospital，现任电子科技大学附属四川省肿瘤医院肿瘤实验研究部（包含肿瘤基础研究中心、肿瘤样本库和放射肿瘤学四川省重点实验室）主任。获得四川省“千人计划”、四川省青年科技奖和四川省医学会优秀论文等奖励。担任中国细胞生物学会类器官分会常务委员、中国医学装备委员会组织再生分会常务委员和四川省口腔医学会口腔材料分会副主任委员等学术职务。获得加拿大CIHR、中央引导地方重点项目和四川省国际科技创新合作重大项目等国家和省部级11项资助。在Nature Neuroscience、Molecular Therapy、Journal of Neuroinflammation、Stroke和Cell Proliferation等杂志发表论文60余篇。

研究领域：

1.记忆通胀表型CD8+ T细胞影响肿瘤免疫检查点抑制剂抗肿瘤治疗响应率的免疫学原理和干预策略

2. II型肺泡上皮细胞介导巨噬细胞极化并塑造肺纤维化生态位的生物学机制和干预策略

3. 效应/记忆CD8+ T细胞协同B7.2hi促炎表型小胶质细胞介导自身免疫性神经炎的原理和干预策略

4.病毒前驱感染导致免疫记忆通胀发生的分子机制

研究成果：

1. Shi Z, Wang X, Wang J, Chen H, Du Q, Lang Y, Kong L, Luo W, Qiu Y, Zhang Y, Li C, Wen D, Yao J, Cheng X, Cai L, Lin X, Wang R, Mou Z, Li S, Liu D, Zhou H, Zhou H, Yang M., Granzyme B + CD8 + T cells with terminal differentiated effector signature determine multiple sclerosis progression. J Neuroinflammation. 2023 Jun 2;20(1):138. IF=9.6/JCR1

2. He Q, Zhou Y, Zhou J, Zhao D, Li L, Li X, Huang Y, Wang Q, Zou H, Zhang K, Li Y, Wang Z, Deng Y, Meng F, Ying B, Yang M, Wang D., Clinical relevance of plasma EBV DNA as a biomarker for nasopharyngeal carcinoma in non-endemic areas: A multicenter study in southwestern China. Clin Chim Acta. 2023 Feb 15;541:117244. IF=6.3/JCR2

3. Shi Z, Du Q, Wang X, Wang J, Chen H, Lang Y, Kong L, Luo W, Yang M, Zhou H., Granzyme B in circulating CD8+ T cells as a biomarker of immunotherapy effectiveness and disability in neuromyelitis optica spectrum disorders. Front Immunol. 2022 Nov 9;13:1027158. IF=8.8/JCR1

4. Wen D, Wang X, Chen R, Li H, Zheng J, Fu W, Zhang T, Yang M, You C, Ma L., Single-Cell RNA Sequencing Reveals the Pathogenic Relevance of Intracranial Atherosclerosis in Blood Blister-Like Aneurysms. Front Immunol. 2022 Jul 8;13:927125. IF=8.8/JCR1

5. Wen D, Chen R, Li H, Zheng J, Fu W, Shi Z, You C, Yang M, Ma L., Reduced M2 macrophages and adventitia collagen dampen the structural integrity of blood blister-like aneurysms and induce preoperative rerupture. Cell Prolif. 2022 Feb;55(2):e13175. IF=8.8/JCR1

6. Liu X, Yu Z, Wu Y, Shi S, Yao J, Feng X, Wen D, Shi Z, Zhao Z, Li Y, Zhou H, You C, Lin Y, Yang M., The immune regulatory effects of tetrahedral framework nucleic acid on human T cells via the mitogen-activated protein kinase pathway. Cell Prolif. 2021 Aug;54(8):e13084. IF=8.8/JCR1

7. Oladiran O, Shi XQ, Yang M, Fournier S, Zhang J., Inhibition of TLR4 signaling protects mice from sensory and motor dysfunction in an animal model of autoimmune peripheral neuropathy. J Neuroinflammation. 2021 Mar 22;18(1):77. IF=9.6/JCR1

8. Shi Z, Qiu Y, Zhao Z, Wen D, Chen H, Du Q, Zhang Y, Wang J, Yan C, Yang M, Zhou H., CD8+ T cell subpopulations and pro-inflammatory cytokines in neuromyelitis optica spectrum disorder. Ann Clin Transl Neurol. 2021 Jan;8(1):43-53. IF=5.4/JCR1

9. Wen D, Kieran NW, Yang M., Letter by Wen et al Regarding Article, "Pathophysiology of Intracranial Aneurysms: COX-2 Expression, Iron Deposition in Aneurysm Wall, and Correlation With Magnetic Resonance Imaging". Stroke. 2020 Dec;51(12):e367-e368. IF=10.2/JCR1

10. Wen D, Xiao Y, Yang M., Letter by Wen et al Regarding Article, "Increased Wall Enhancement During Follow-Up as a Predictor of Subsequent Aneurysmal Growth". Stroke. 2020 Oct;51(10):e293-e294. IF=10.2/JCR1

11. Shi Z, Du Q, Chen H, Zhang Y, Qiu Y, Zhao Z, Wang J, Yan C, Zhang Q, Yang M, Zhou H., Effects of immunotherapies and prognostic predictors in neuromyelitis optica spectrum disorder: a prospective cohort study. J Neurol. 2020 Apr;267(4):913-924. IF=6.7/JCR1

12. Zhang F, Ren Y, Fu W, Wang Y, Qian J, Tao C, You C, Yang M., Association between neutrophil to lymphocyte ratio and blood glucose level at admission in patients with spontaneous intracerebral hemorrhage. Sci Rep. 2019 Oct 30;9(1):15623. IF=5/JCR2

13. Wen D, Ma L, Yang M., Letter by Wen et al Regarding Article, "Validation of Wall Enhancement as a New Imaging Biomarker of Unruptured Cerebral Aneurysm". Stroke. 2019 Oct;50(10):e305. IF=10.2/JCR1

14. Yang M, Shi XQ, Peyret C, Oladiran O, Wu S, Chambon J, Fournier S, Zhang J., Effector/memory CD8+ T cells synergize with co-stimulation competent macrophages to trigger autoimmune peripheral neuropathy. Brain Behav Immun. 2018 Jul;71:142-157. IF=19.2/JCR1

15. Wang GYF, Shi XQ, Wu W, Gueorguieva M, Yang M, Zhang J., Sustained and repeated mouth opening leads to development of painful temporomandibular disorders involving macrophage/microglia activation in mice. Pain. 2018 Jul;159(7):1277-1288. IF=7.9/JCR1

16. Echeverry S, Shi XQ, Yang M, Huang H, Wu Y, Lorenzo LE, Perez-Sanchez J, Bonin RP, De Koninck Y, Zhang J., Spinal microglia are required for long-term maintenance of neuropathic pain. Pain. 2017 Sep;158(9):1792-1801. IF=7.9/JCR1

17. Yao Y, Echeverry S, Shi XQ, Yang M, Yang QZ, Wang GY, Chambon J, Wu YC, Fu KY, De Koninck Y, Zhang J., Dynamics of spinal microglia repopulation following an acute depletion. Sci Rep. 2016 Mar 10;6:22839. IF=5/JCR2

18. Yang M, Peyret C, Shi XQ, Siron N, Jang JH, Wu S, Fournier S, Zhang J., Evidence from Human and Animal Studies: Pathological Roles of CD8(+) T Cells in Autoimmune Peripheral Neuropathies. Front Immunol. 2015 Oct 15;6:532. IF=8.8/JCR1

19. Sorge RE, Mapplebeck JC, Rosen S, Beggs S, Taves S, Alexander JK, Martin LJ, Austin JS, Sotocinal SG, Chen D, Yang M, Shi XQ, Huang H, Pillon NJ, Bilan PJ, Tu Y, Klip A, Ji RR, Zhang J, Salter MW, Mogil JS., Different immune cells mediate mechanical pain hypersensitivity in male and female mice. Nat Neurosci. 2015 Aug;18(8):1081-3. IF=28.8/JCR1

20. Yang M, Rainone A, Shi XQ, Fournier S, Zhang J., A new animal model of spontaneous autoimmune peripheral polyneuropathy: implications for Guillain-Barré syndrome. Acta Neuropathol Commun. 2014 Jan 8;2:5. IF=7.6/JCR1