杨牧，博士，教授，博士研究生导师。主要研究方向：1、记忆通胀介导重大疾病演进的免疫学机制；2、宿主免疫异质性的生物学原理与干预策略。

学术经历：

2012年至2019年供职于加拿大McGill大学附属Montréal Neurological Hospital and Institute。2019年4月至今供职于四川省肿瘤医院，任肿瘤实验研究部主任。获得四川省“特聘教授”（2019年）以及四川省青年科技奖（2020年）等学术奖励，发表论文70余篇，总影响因子约330，单篇最高他引500余次。

科研项目：

主持加拿大CIHR、Catherine Bushnell Foundation和四川省国际科技创新合作重大项目等国家和省部级基金8项。

研究成果：

1. Shi Z, Wang X, Wang J, Chen H, Du Q, Lang Y, Kong L, Luo W, Qiu Y, Zhang Y, Li C, Wen D, Yao J, Cheng X, Cai L, Lin X, Wang R, Mou Z, Li S, Liu D, Zhou H, Zhou H, Yang M., Granzyme B + CD8 + T cells with terminal differentiated effector signature determine multiple sclerosis progression. J Neuroinflammation. 2023 Jun 2;20(1):138. IF=9.6/JCR1

2. He Q, Zhou Y, Zhou J, Zhao D, Li L, Li X, Huang Y, Wang Q, Zou H, Zhang K, Li Y, Wang Z, Deng Y, Meng F, Ying B, Yang M, Wang D., Clinical relevance of plasma EBV DNA as a biomarker for nasopharyngeal carcinoma in non-endemic areas: A multicenter study in southwestern China. Clin Chim Acta. 2023 Feb 15;541:117244. IF=6.3/JCR2

3. Shi Z, Du Q, Wang X, Wang J, Chen H, Lang Y, Kong L, Luo W, Yang M, Zhou H., Granzyme B in circulating CD8+ T cells as a biomarker of immunotherapy effectiveness and disability in neuromyelitis optica spectrum disorders. Front Immunol. 2022 Nov 9;13:1027158. IF=8.8/JCR1

4. Wen D, Wang X, Chen R, Li H, Zheng J, Fu W, Zhang T, Yang M, You C, Ma L., Single-Cell RNA Sequencing Reveals the Pathogenic Relevance of Intracranial Atherosclerosis in Blood Blister-Like Aneurysms. Front Immunol. 2022 Jul 8;13:927125. IF=8.8/JCR1

5. Wen D, Chen R, Li H, Zheng J, Fu W, Shi Z, You C, Yang M, Ma L., Reduced M2 macrophages and adventitia collagen dampen the structural integrity of blood blister-like aneurysms and induce preoperative rerupture. Cell Prolif. 2022 Feb;55(2):e13175. IF=8.8/JCR1

6. Liu X, Yu Z, Wu Y, Shi S, Yao J, Feng X, Wen D, Shi Z, Zhao Z, Li Y, Zhou H, You C, Lin Y, Yang M., The immune regulatory effects of tetrahedral framework nucleic acid on human T cells via the mitogen-activated protein kinase pathway. Cell Prolif. 2021 Aug;54(8):e13084. IF=8.8/JCR1

7. Oladiran O, Shi XQ, Yang M, Fournier S, Zhang J., Inhibition of TLR4 signaling protects mice from sensory and motor dysfunction in an animal model of autoimmune peripheral neuropathy. J Neuroinflammation. 2021 Mar 22;18(1):77. IF=9.6/JCR1

8. Shi Z, Qiu Y, Zhao Z, Wen D, Chen H, Du Q, Zhang Y, Wang J, Yan C, Yang M, Zhou H., CD8+ T cell subpopulations and pro-inflammatory cytokines in neuromyelitis optica spectrum disorder. Ann Clin Transl Neurol. 2021 Jan;8(1):43-53. IF=5.4/JCR1

9. Wen D, Kieran NW, Yang M., Letter by Wen et al Regarding Article, "Pathophysiology of Intracranial Aneurysms: COX-2 Expression, Iron Deposition in Aneurysm Wall, and Correlation With Magnetic Resonance Imaging". Stroke. 2020 Dec;51(12):e367-e368. IF=10.2/JCR1

10. Wen D, Xiao Y, Yang M., Letter by Wen et al Regarding Article, "Increased Wall Enhancement During Follow-Up as a Predictor of Subsequent Aneurysmal Growth". Stroke. 2020 Oct;51(10):e293-e294. IF=10.2/JCR1

11. Shi Z, Du Q, Chen H, Zhang Y, Qiu Y, Zhao Z, Wang J, Yan C, Zhang Q, Yang M, Zhou H., Effects of immunotherapies and prognostic predictors in neuromyelitis optica spectrum disorder: a prospective cohort study. J Neurol. 2020 Apr;267(4):913-924. IF=6.7/JCR1

12. Zhang F, Ren Y, Fu W, Wang Y, Qian J, Tao C, You C, Yang M., Association between neutrophil to lymphocyte ratio and blood glucose level at admission in patients with spontaneous intracerebral hemorrhage. Sci Rep. 2019 Oct 30;9(1):15623. IF=5/JCR2

13. Wen D, Ma L, Yang M., Letter by Wen et al Regarding Article, "Validation of Wall Enhancement as a New Imaging Biomarker of Unruptured Cerebral Aneurysm". Stroke. 2019 Oct;50(10):e305. IF=10.2/JCR1

14. Yang M, Shi XQ, Peyret C, Oladiran O, Wu S, Chambon J, Fournier S, Zhang J., Effector/memory CD8+ T cells synergize with co-stimulation competent macrophages to trigger autoimmune peripheral neuropathy. Brain Behav Immun. 2018 Jul;71:142-157. IF=19.2/JCR1

15. Wang GYF, Shi XQ, Wu W, Gueorguieva M, Yang M, Zhang J., Sustained and repeated mouth opening leads to development of painful temporomandibular disorders involving macrophage/microglia activation in mice. Pain. 2018 Jul;159(7):1277-1288. IF=7.9/JCR1

16. Echeverry S, Shi XQ, Yang M, Huang H, Wu Y, Lorenzo LE, Perez-Sanchez J, Bonin RP, De Koninck Y, Zhang J., Spinal microglia are required for long-term maintenance of neuropathic pain. Pain. 2017 Sep;158(9):1792-1801. IF=7.9/JCR1

17. Yao Y, Echeverry S, Shi XQ, Yang M, Yang QZ, Wang GY, Chambon J, Wu YC, Fu KY, De Koninck Y, Zhang J., Dynamics of spinal microglia repopulation following an acute depletion. Sci Rep. 2016 Mar 10;6:22839. IF=5/JCR2

18. Yang M, Peyret C, Shi XQ, Siron N, Jang JH, Wu S, Fournier S, Zhang J., Evidence from Human and Animal Studies: Pathological Roles of CD8(+) T Cells in Autoimmune Peripheral Neuropathies. Front Immunol. 2015 Oct 15;6:532. IF=8.8/JCR1

19. Sorge RE, Mapplebeck JC, Rosen S, Beggs S, Taves S, Alexander JK, Martin LJ, Austin JS, Sotocinal SG, Chen D, Yang M, Shi XQ, Huang H, Pillon NJ, Bilan PJ, Tu Y, Klip A, Ji RR, Zhang J, Salter MW, Mogil JS., Different immune cells mediate mechanical pain hypersensitivity in male and female mice. Nat Neurosci. 2015 Aug;18(8):1081-3. IF=28.8/JCR1

20. Yang M, Rainone A, Shi XQ, Fournier S, Zhang J., A new animal model of spontaneous autoimmune peripheral polyneuropathy: implications for Guillain-Barré syndrome. Acta Neuropathol Commun. 2014 Jan 8;2:5. IF=7.6/JCR1